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Piperine, a Phytochemical Potentiator of Ciprofloxacin against Staphylococcus aureus

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Title Piperine, a Phytochemical Potentiator of Ciprofloxacin against Staphylococcus aureus
 
Creator Khan, I. A.
Mirza, Z. M.
Kumar, A.
Verma, V.
Qazi, G. N.
 
Subject Pharmacological Sciences
 
Description Piperine, a trans-trans isomer of 1-piperoyl-piperidine, in combination with ciprofloxacin markedly reduced
the MICs and mutation prevention concentration of ciprofloxacin for Staphylococcus aureus, including methicillin-resistant S. aureus. The enhanced accumulation and decreased efflux of ethidium bromide in the wild-type
and mutant (CIPr-1) strains in the presence of piperine suggest its involvement in the inhibition of bacterial
efflux pumps.
 
Date 2006
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://iiim.csircentral.net/379/1/10.1128AAC.50.2.810%E2%80%93812.2006.pdf
Khan, I. A. and Mirza, Z. M. and Kumar, A. and Verma, V. and Qazi, G. N. (2006) Piperine, a Phytochemical Potentiator of Ciprofloxacin against Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 50 (2). pp. 810-812. ISSN 0066-4804
 
Relation http://dx.doi.org/10.1128/AAC.50.2.810-812.2006
http://iiim.csircentral.net/379/