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Remarkable synergism in methylimidazole-promoted decarboxylation of substituted cinnamic acid derivatives in basic water medium under microwave irradiation: a clean synthesis of hydroxylated (E)-stilbenes*
IR@CSIR-IHBT
View Archive Info| Field | Value | |
| Title |
Remarkable synergism in methylimidazole-promoted decarboxylation of substituted cinnamic acid derivatives in basic water medium under microwave irradiation: a clean synthesis of hydroxylated (E)-stilbenes* |
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| Creator |
Kumar , V
Sharma, A Sharma, A Sinha, Arun K |
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| Subject |
Natural Product Chemistry
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| Description |
A metal-free protocol for decarboxylation of substituted a-phenylcinnamic acid derivatives in aqueous media is developed, wherein a remarkable synergism between methylimidazole and aq NaHCO3 in polyethylene glycol under microwave furnished the corresponding para/ortho hydroxylated (E)-stilbenes in a mild and efficient manner. The critical role of water in facilitating the decarboxylation imparts an interesting facet to the synthetic utility of water mediated organic transformations. The developed protocol provides a clean alternative to the hitherto indispensable multistep approaches involving toxic quinoline and a copper salt combination as the common decarboxylating agent. |
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| Date |
2007
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| Type |
Article
PeerReviewed |
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| Identifier |
Kumar , V and Sharma, A and Sharma, A and Sinha, Arun K (2007) Remarkable synergism in methylimidazole-promoted decarboxylation of substituted cinnamic acid derivatives in basic water medium under microwave irradiation: a clean synthesis of hydroxylated (E)-stilbenes*. Tetrahedron, 63. pp. 7640-7646.
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| Relation |
http://ihbt.csircentral.net/530/
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