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Selective Th2 Upregulation by Crocus sativus : A Neutraceutical Spice

IR@CSIR-IHBT

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Title Selective Th2 Upregulation by Crocus sativus :
A Neutraceutical Spice
 
Creator Bani , S
Pandey, A
Agnihotri, V K
Pathania, V
Singh , Bikram
 
Subject Natural Product Chemistry
 
Description The immunomodulatory activity of an Indian neutraceutical spice, saffron (Crocus sativus) was studied on Th1 and Th2 limbs of
the immune system. Oral administration of alcoholic extract of Crocus sativus (ACS) at graded dose levels from1.56–50 mg/kg p.o.
potentiated the Th2 response of humoral immunity causing the significant increases in agglutinating antibody titre in mice at a
dose of 6.25 mg/kg and an elevation of CD19+ B cells and IL-4 cytokine, a signature cytokine of Th2 pathway. Appreciable elevation
in levels of IgG-1 and IgM antibodies of the primary and secondary immune response was observed. However, ACS showed no
appreciable expression of the Th1 cytokines IL-2 (growth factor for CD4+ T cells) and IFN-γ (signature cytokine of Th1 response).
A significant modulation of immune reactivity was observed in all the animal models used. This paper represents the selective
upregulation of the Th2 response of the test material and suggests its use for subsequent selective Th2 immunomodulation.
 
Date 2010
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://ihbt.csircentral.net/611/1/485_20119-12-2011.pdf
Bani , S and Pandey, A and Agnihotri, V K and Pathania, V and Singh , Bikram (2010) Selective Th2 Upregulation by Crocus sativus : A Neutraceutical Spice. Evidence-Based Complementary and Alternative Medicine , 10. pp. 639-862.
 
Relation http://ihbt.csircentral.net/611/