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Antimutagenic and Antioxidant Characteristics of Chukrasia tabularis A Juss Extracts

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Title Antimutagenic and Antioxidant Characteristics of Chukrasia tabularis A Juss Extracts
 
Creator Kaur, R
Sharma, U
Singh , Bikram
Arora, S
 
Subject Natural Product Chemistry
 
Description The current study aims to evaluate the antioxidative and antimutagenic activities of methanol extract and different fractions of Chukrasia tabularis leaves. The antioxidative potential was evaluated using 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) cation and superoxide anion radical-scavenging assay. The antimutagenic potential was evaluated against direct-acting mutagens, 4-nitro-o-phenylenediamine and sodium azide; and S9-dependent mutagen, 2-aminofluorene in TA98 and TA100 strains of Salmonella typhimurium using Ames assay. It has been found that methanol extract and its fractions were more efficient against S9-dependent mutagen in pre-incubation mode of treatment as compared to direct-acting mutagens in both the strains. Methanol extract and its fractions also exhibited strong radical-scavenging potential. High-performance liquid chromatography (HPLC) analysis of methanol extract showed the presence of gallic acid, epicatechin, 7-hydroxycoumarin, and rutin. From the study, it could be concluded that antioxidative and antimutagenic activity of methanol extract and its fractions was related to the synergistic interactions among different chemical compounds
 
Date 2011
 
Type Article
PeerReviewed
 
Identifier Kaur, R and Sharma, U and Singh , Bikram and Arora, S (2011) Antimutagenic and Antioxidant Characteristics of Chukrasia tabularis A Juss Extracts. International Journal of Toxicology, 30 (1). pp. 21-34.
 
Relation http://ihbt.csircentral.net/647/