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The basic and applied aspects of superoxide dismutase.

IR@CSIR-IHBT

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Title The basic and applied aspects of superoxide dismutase.
 
Creator Bafana, A
Dutt, Som
Kumar, Amit
Kumar, Sanjay
Ahuja, Paramvir Singh
 
Subject Nutraceuticals
Plant Biotechnology
 
Description Superoxide dismutase (SOD) is among the most potent antioxidants known in nature and is an important constituent of cellular defence against oxidative stress. The enzyme shows several interesting properties like very high catalytic rate of reaction and high stability to physico-chemical stress. It has also attracted widespread interest due to its therapeutic potential. Oxidative stress is known to be involved in pathophysiology of several diseases and SOD supplementation has been shown to be beneficial in treatment or prevention of such diseases. However, it is yet to be developed into effective, reliable and safe antioxidant therapy. Current review focuses on the physiological importance of SOD, and developments and obstacles in its therapeutic applications for treatment of various disorders. The review also summarizes SOD-based products and patents, its potentiation to improve efficacy, and major clinical trials of SOD in human subjects. Besides, latest literature on phylogeny and biochemistry of the enzyme is also reviewed.
 
Date 2011
 
Type Article
PeerReviewed
 
Identifier Bafana, A and Dutt, Som and Kumar, Amit and Kumar, Sanjay and Ahuja, Paramvir Singh (2011) The basic and applied aspects of superoxide dismutase. Journal of Molecular Catalysis B:Enzymatic, 68. pp. 129-138.
 
Relation http://ihbt.csircentral.net/649/