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Evaluation of antigenotoxic activity of isoliquiritin apioside from Glycyrrhiza glabra L.

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Title Evaluation of antigenotoxic activity of isoliquiritin apioside from Glycyrrhiza glabra L.
 
Creator Kaur, P
Kaur, S
Kumar, Neeraj
Singh , Bikram
Kumar, Sanjay
 
Subject Natural Product Chemistry
 
Description a b s t r a c t
Prevention of manifestation of events characteristic of carcinogenesis is being emphasized a rational
strategy to combat cancer. Reactive oxygen species (ROS) play an important role in tumor initiation
through oxidative damage of DNA. In search for lead molecules in cancer chemoprevention from natural
products, a fraction ‘Rlicca’ isolated from Glycyrrhiza glabra was studied for modulatory effect against
hydrogen peroxide and 4-nitroquinoline-N-oxide induced genotoxicity in Escherichia coli PQ37 using
SOS chromotest and in human peripheral blood lymphocytes using the Comet assay. The fraction ‘Rlicca’
at a concentration of 191 lM decreased the SOS inducing potency (SOSIP) of hydrogen peroxide (1.0 mM)
and NQO (20 lg/ml) by 83.72% and 68.77%, respectively. In the human blood lymphocytes, ‘Rlicca’
reduced the tail moment induced by hydrogen peroxide (25 lM) and NQO (5 lg/ml) by 88.04% and
76.64%, respectively, using the Comet assay. The spectroscopic data of ‘Rlicca’ fraction revealed it to be
isoliquiritin apioside, a chalcone oligoglycoside. This is the first report of isoliquiritin apioside with
marked potential to combat oxidative stress-induced genotoxicity.
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://ihbt.csircentral.net/892/1/ATT00041.pdf
Kaur, P and Kaur, S and Kumar, Neeraj and Singh , Bikram and Kumar, Sanjay (2009) Evaluation of antigenotoxic activity of isoliquiritin apioside from Glycyrrhiza glabra L. Toxicology in vitro, 23. pp. 680-686.
 
Relation http://ihbt.csircentral.net/892/