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Development of biodegradable nanoparticles for delivery of quercetin

IR@CSIR-IHBT

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Field Value
 
Title Development of biodegradable nanoparticles for delivery of quercetin
 
Creator Kumari, A
Yadav , S K
Pakade, Yogesh B
Singh , Bikram
Yadav, S C
 
Subject Plant sciences
 
Description The antioxidant molecule quercetin has been encapsulated on poly-d,l-lactide (PLA) nanoparticles by
solvent evaporation method for the improvement of its poor aqueous solubility and stability. The surface
morphology and average size of PLA and quercetin loaded PLA nanoparticles are 170±25 and 130±30nm
respectively. The antioxidant activities of the PLA encapsulated quercetin nanomedicine are identical to
free quercetin. The nanoencapsulation efficiency of quercetin evaluated by HPLC and antioxidant assay
is 96.7%. The in vitro release kinetics under physiological condition show initial burst release followed
by slow and sustained release. The complete release and maximum retention of quercetin is 72 and
96 h respectively. The less fluorescence quenching efficiency of quercetin–PLA nanoparticles than free
quercetin on BSA confirms the controlled release of quercetin from PLA nanoparticles. These properties
of PLA encapsulated quercetin molecule pave way for encapsulating various therapeutically less useful
highly active antioxidant molecules towards the development of better therapeutic compounds.
 
Date 2010
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://ihbt.csircentral.net/919/1/Quercetin_paper.pdf
Kumari, A and Yadav , S K and Pakade, Yogesh B and Singh , Bikram and Yadav, S C (2010) Development of biodegradable nanoparticles for delivery of quercetin. Colloids and Surfaces B: Biointerfaces, 80. pp. 184-192.
 
Relation http://ihbt.csircentral.net/919/