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Pd-Catalyzed Orthogonal Knoevenagel/Perkin Condensation– Decarboxylation–Heck/Suzuki Sequences: Tandem Transformations of Benzaldehydes into Hydroxy-Functionalized Antidiabetic Stilbene– Cinnamoyl Hybrids and Asymmetric Distyrylbenzenes

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Title Pd-Catalyzed Orthogonal Knoevenagel/Perkin Condensation–
Decarboxylation–Heck/Suzuki Sequences: Tandem Transformations of
Benzaldehydes into Hydroxy-Functionalized Antidiabetic Stilbene–
Cinnamoyl Hybrids and Asymmetric Distyrylbenzenes
 
Creator Sharma, N
Sharma , A
Shard, A
Kumar, R
---, Saima
Sinha, Arun K
 
Subject Plant sciences
Natural Product Chemistry
 
Description Abstract: Tandem reactions that involve chemoselective Knoevenagel/Perkin condensation–
decarboxylation–Heck/Suzuki coupling or Heck–aldol sequences have
been achieved. This enabled the first concise and efficient synthesis of several important
hydroxy-functionalized compound classes, such as stilbene–cinnamoyl hybrids
(potent protein tyrosine phosphatase1B inhibitors), cinnamoyl–cinnamic acid
hybrids, asymmetric distyrylbenzenes, and biarylstyrenes. Previously reported synthesis
require multiple steps and protection/deprotection manipulations
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://ihbt.csircentral.net/941/1/31-01-2012_Catalyzed.pdf
Sharma, N and Sharma , A and Shard, A and Kumar, R and ---, Saima and Sinha, Arun K (2011) Pd-Catalyzed Orthogonal Knoevenagel/Perkin Condensation– Decarboxylation–Heck/Suzuki Sequences: Tandem Transformations of Benzaldehydes into Hydroxy-Functionalized Antidiabetic Stilbene– Cinnamoyl Hybrids and Asymmetric Distyrylbenzenes. Chemistry A European Journal, 17 (10). pp. 350-356.
 
Relation http://ihbt.csircentral.net/941/