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Silica-Supported Boric Acid with Ionic Liquid: A Novel Recyclable Catalytic System for One-Pot Three-Component Mannich Reaction

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Title Silica-Supported Boric Acid with Ionic Liquid: A Novel Recyclable
Catalytic System for One-Pot Three-Component Mannich Reaction
 
Creator Kumar, Vishal
Sharma, U
Kumar, P
Kumar, Neeraj
Singh , Bikram
 
Subject Plant sciences
Natural Product Chemistry
 
Description A rapid and efficient silica-supported boric acid/ionic liquid ([bmim][PF6]), catalyzed, one-pot three-component
Mannich reaction has been carried out to synthesize b -amino carbonyl compounds at room temperature.
The reaction afforded desired products in excellent yields with moderate to good diastereoselectivity. The method
provides a novel modification of three-component Mannich reaction in terms of mild reaction conditions, clean
reaction profiles, low amount of catalyst, recyclability of catalyst and a simple workup procedure. The present
report first time describes the preparation of H3BO3–SiO2 catalyst and its use with [bmim][PF6], to synthesize
Mannich products. The catalyst can be reused at least seven times.
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://ihbt.csircentral.net/944/1/31-01-2012_Silica.pdf
Kumar, Vishal and Sharma, U and Kumar, P and Kumar, Neeraj and Singh , Bikram (2011) Silica-Supported Boric Acid with Ionic Liquid: A Novel Recyclable Catalytic System for One-Pot Three-Component Mannich Reaction. Journal of Chemistry.Pharm.Bull, 59 (5). pp. 639-645.
 
Relation http://ihbt.csircentral.net/944/