Amine and thiazole substituted !-butyrolactones from naturally occurring limonene
IR@CSIR-IHBT
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Title |
Amine and thiazole substituted !-butyrolactones from naturally occurring limonene |
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Creator |
Kaur, P
Das, Pralay Chaudhary, A Singh , Bikram |
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Subject |
Plant sciences
Natural Product Chemistry |
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Description |
Abstract: Substituted g-butyrolactones are important structural motifs in several natural products and pharmaceuticals. In this paper, we report the synthesis of novel g-butyrolactone amine and thiazole derivatives from naturally occurring limonene. Regioselective bromination followed by nucleophilic substitution with different amines and thiourea gave desired products in moderate yield. Key words: regioselectivity, bromination, amination, thiazole, g-butyrolactone. Résumé : Les g-butyrolactones substituées sont d’importants motifs structuraux dans plusieurs produits naturels et pharmaceutiques. Dans ce travail, on a synthétisé de nouveaux dérivés amine et thiazole de la g-butyrolactone à partir du limonène qu’on peut obtenir de sources naturelles. La bromation régiosélective, suivie d’une substitution nucléophile avec diverses amines et thiourées permet d’obtenir les produits désirés avec des rendements modérés |
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Date |
2011
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Type |
Article
PeerReviewed |
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Format |
application/pdf
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Identifier |
http://ihbt.csircentral.net/961/1/Amine_and_thiazole_substituted_%21-butyrolactones.pdf
Kaur, P and Das, Pralay and Chaudhary, A and Singh , Bikram (2011) Amine and thiazole substituted !-butyrolactones from naturally occurring limonene. Journal of Chemistry, 89. pp. 639-644. |
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Relation |
http://ihbt.csircentral.net/961/
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