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One-Pot Multicomponent Michael and Thorpe-Ziegler Reaction of Aryl Methyl Ketones

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Title One-Pot Multicomponent Michael and Thorpe-Ziegler Reaction of Aryl
Methyl Ketones
 
Creator Jaitak, V
---, Bandna
Das, Pralay
Kaul , V K
Singh , Bikram
Kumar, Neeraj
 
Subject Plant sciences
Natural Product Chemistry
 
Description Abstract A regioselective base-promoted Michael and Thorpe–Ziegler reaction between
aryl methyl ketones and a,b-unsaturated nitrile was carried out in a single step. Different
functional groups in addition to active positions were tolerated under this condition. Results
indicated that the reaction proceeds in a consecutive manner as double Michael, triple
Michael, and Thorpe–Ziegler condensation. By applying click chemistry, double Michael
adducts were converted to bis-tetrazoles, which have broad applications in coordination
and medicinal chemistry.
Supplemental materials are available for this article. Go to the publisher’s online edition
of Synthetic Communications1 to view the free supplemental file
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://ihbt.csircentral.net/966/1/Synthetic_communication.pdf
Jaitak, V and ---, Bandna and Das, Pralay and Kaul , V K and Singh , Bikram and Kumar, Neeraj (2011) One-Pot Multicomponent Michael and Thorpe-Ziegler Reaction of Aryl Methyl Ketones. Journal of Synthetic Communications, 41. pp. 2727-2737.
 
Relation http://ihbt.csircentral.net/966/