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Antimutagenic potential of chickrassy (Chukrasia tabularis A. Juss.) bark

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Title Antimutagenic potential of chickrassy (Chukrasia
tabularis A. Juss.) bark
 
Creator Kaur, R
Sharma , U
Singh , Bikram
Arora, S
 
Subject Plant sciences
Natural Product Chemistry
 
Description The present study aims to assess the antimutagenic potential of methanol extract and different
fractions (hexane, ethyl acetate and butanol) of chickrassy (Chukrasia tabularis), belonging to family
meliaceae by employing histidine point reversion assay. The antimutagenic effect was evaluated
against mutagens, 4-Nitro-o-phenylenediamine and sodium azide and promutagen, 2-Aminofluorene of
TA98 and TA100 strain of Salmonella typhimurium. The co-incubation and pre-incubation mode of
treatments were used to evaluate the bioantimutagenic and desmutagenic effects, respectively. From
the results obtained, it was clear that methanol extract and its fractions showed more desmutagenic
effect than bioantimutagenic effect. The methanol extract was found to be most active in TA98 while
ethyl acetate fraction showed good results in TA100 strain against both promutagen and direct acting
mutagen. High performance liquid chromatography (HPLC) analysis of methanol extract was carried out
for the identification of chemical constituents and the results revealed that catechin, quercetin and rutin
have contributed to its antimutagenic activity.
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://ihbt.csircentral.net/1047/1/34_Antimutagenic_2011.pdf
Kaur, R and Sharma , U and Singh , Bikram and Arora, S (2011) Antimutagenic potential of chickrassy (Chukrasia tabularis A. Juss.) bark. Journal of Medicinal Plants Research, 5 (20). pp. 5021-5033.
 
Relation http://ihbt.csircentral.net/1047/