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Immunomodulatory active steroidal saponins from Asparagus racemosus

IR@CSIR-IHBT

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Field Value
 
Title Immunomodulatory active steroidal saponins from Asparagus
racemosus
 
Creator Sharma, U
Kumar , Neeraj
Singh , Bikram
R K, Munshi
 
Subject Plant sciences
Natural Product Chemistry
 
Description Asparagus racemosus is used in the Indian
traditional system of medicine for improving the general
state of health and stress-related immune disorders. Most of
the synthetic chemotherapeutic agents available today are
immunosuppressants and exert variety of side effects. To
overcome these undesired effects of chemotherapeutic
agents, botanical-based immunomodulators are often
employed as adjuvant therapy. In the present study,
immunomodulatory activity of two steroidal saponins
shatavaroside A (1) and shatavaroside B (2), isolated from
Asparagus racemosus, have been evaluated using polymorphonuclear
leucocyte function test. The activity was
further confirmed using more sensitive assays such as
nitroblue tetrazolium, nitrous oxide, and chemiluminescence
assays. Both steroidal saponins were found active at
nano concentration (5 ng/ml) and can act as potent
immunostimulants
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://ihbt.csircentral.net/1091/1/20_Immunomodulatory.pdf
Sharma, U and Kumar , Neeraj and Singh , Bikram and R K, Munshi (2011) Immunomodulatory active steroidal saponins from Asparagus racemosus. Medicinal Chemistry Research.
 
Relation http://ihbt.csircentral.net/1091/