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Chalcones as promising pesticidal agents against diamondback moth (Plutella xylostella): microwave-assisted synthesis and structure–activity relationship

IR@CSIR-IHBT

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Title Chalcones as promising pesticidal agents against diamondback
moth (Plutella xylostella): microwave-assisted synthesis
and structure–activity relationship
 
Creator Kumar , Rakesh
Sharma , Prabha
Shard , Amit
Tewary, D K
Nadda , Gireesh
Sinha, Arun K
 
Subject Natural Product Chemistry
Pest and Pesticides
 
Description A series of chalcones (A–CH=CH–CO–B)
were synthesized under microwave irradiation, and for the
first time their pesticidal activity against diamondback
moth (Plutella xylostella) was evaluated to identify the
promising lead structures. The structure–activity relationship
(SAR) analysis revealed that electron-withdrawing
substituents on ring A of chalcone provided good pesticidal
agents, whereas, ring B can bear either electron-withdrawing
or electron-releasing substituents. Moreover,
compound 22 having para-Cl substitution on ring A as well
on ring B showed maximum activity with LC50 value of
170.24 lg mL-1.
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://ihbt.csircentral.net/1204/1/7_Chalcones_as_promising.pdf
Kumar , Rakesh and Sharma , Prabha and Shard , Amit and Tewary, D K and Nadda , Gireesh and Sinha, Arun K (2012) Chalcones as promising pesticidal agents against diamondback moth (Plutella xylostella): microwave-assisted synthesis and structure–activity relationship. Medicinal Chemistry Research, 21. pp. 922-931.
 
Relation http://ihbt.csircentral.net/1204/