Record Details

Synthesis of substituted amines and isoindolinones: catalytic reductive amination using abundantly available AlCl3/PMHS

IR@CSIR-IHBT

View Archive Info
 
 
Field Value
 
Title Synthesis of substituted amines and isoindolinones: catalytic reductive
amination using abundantly available AlCl3/PMHS
 
Creator Kumar, Vishal
Sharma, Sushila
Sharma, U
Singh , Bikram
Kumar, Neeraj
 
Subject Natural Product Chemistry
 
Description AlCl3 has been employed for highly chemoselective reductive amination of carbonyl compounds in
ethanol using polymethylhydrosiloxane as an inexpensive, stable and safe reducing agent without an inert
atmosphere. A large range of functional groups such as nitro, carboxylic acid, acetyl, nitrile, halogen,
methoxy, alkene and heterocycles were well tolerated. AlCl3 also catalyzed tandem amination–amidation
of 2-carboxybenzaldehyde with different amines to afford N-substituted isoindolinones. The catalyst can
be recycled at least three times without any significant effect on activity and selectivity.
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://ihbt.csircentral.net/1234/1/38_Synthesis.pdf
Kumar, Vishal and Sharma, Sushila and Sharma, U and Singh , Bikram and Kumar, Neeraj (2012) Synthesis of substituted amines and isoindolinones: catalytic reductive amination using abundantly available AlCl3/PMHS. Green Chmistry, 14. pp. 3410-3414.
 
Relation http://ihbt.csircentral.net/1234/