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Plant Extract Synthesized PLA Nanoparticles for Controlled and Sustained Release of Quercetin: A Green Approach

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Title Plant Extract Synthesized PLA Nanoparticles for
Controlled and Sustained Release of Quercetin: A Green
Approach
 
Creator Kumari, A
Kumar, Vineet
Yadav , S K
 
Subject Nanotechnology
 
Description Background: Green synthesis of metallic nanoparticles (NPs) has been extensively carried out by using plant extracts (PEs)
which have property of stabilizers/ emulsifiers. To our knowledge, there is no comprehensive study on applying a green
approach using PEs for fabrication of biodegradable PLA NPs. Conventional methods rely on molecules like polyvinyl
alcohol, polyethylene glycol, D-alpha-tocopheryl poly(ethylene glycol 1000) succinate as stabilizers/emulsifiers for the
synthesis of such biodegradable NPs which are known to be toxic. So, there is urgent need to look for stabilizers which are
biogenic and non-toxic. The present study investigated use of PEs as stabilizers/emulsifiers for the fabrication of stable PLA
NPs. Synthesized PLA NPs through this green process were explored for controlled release of the well known antioxidant
molecule quercetin.
Methodology/Principal Findings: Stable PLA NPs were synthesized using leaf extracts of medicinally important plants like
Syzygium cumini (1), Bauhinia variegata (2), Cedrus deodara (3), Lonicera japonica (4) and Eleaocarpus sphaericus (5). Small
and uniformly distributed NPs in the size range 70630 nm to 143636 nm were formed with these PEs. To explore such NPs
for drugs/ small molecules delivery, we have successfully encapsulated quercetin a lipophilic molecule on a most uniformly
distributed PLA-4 NPs synthesized using Lonicera japonica leaf extract. Quercetin loaded PLA-4 NPs were observed for slow
and sustained release of quercetin molecule.
Conclusions: This green approach based on PEs mediated synthesis of stable PLA NPs pave the way for encapsulating drug/
small molecules, nutraceuticals and other bioactive ingredients for safer cellular uptake, biodistribution and targeted
delivery. Hence, such PEs synthesized PLA NPs would be useful to enhance the therapeutic efficacy of encapsulated small
molecules/drugs. Furthermore, different types of plants can be explored for the synthesis of PLA as well as other polymeric
NPs of smaller size.
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://ihbt.csircentral.net/1296/1/75_Plant_Extract.pdf
Kumari, A and Kumar, Vineet and Yadav , S K (2012) Plant Extract Synthesized PLA Nanoparticles for Controlled and Sustained Release of Quercetin: A Green Approach. Journal of PloS one, 7 (7). p. 1230.
 
Relation http://ihbt.csircentral.net/1296/