Record Details

Therapeutic Potential of Natural Products from Terrestrial Plants as TNF-α Antagonist

IR@CSIR-IHBT

View Archive Info
 
 
Field Value
 
Title Therapeutic Potential of Natural Products from Terrestrial Plants as TNF-α Antagonist
 
Creator Verma , Praveen Kumar
Bala , Manju
Kumar, Neeraj
Singh , Bikram
 
Subject Plant sciences
Natural Product Chemistry
 
Description Tumor necrosis fector-alpha (TNF-α) is a multifunctional cytokine produced hy nmnocytes. nwcrophages, neutrophils. T-cdls. masl cdls, epithelial cells. ostenhlasts and dendritic cells. It can regulate numerous cellular and hiological processes such as immune function,cell differentiation. proliferation. apoptosis and energy metaholism. It lS also involved in the pathogenesis of multiple chronic inflammatorY or autoimmune diseases. The biologica1 activities of TNF-α mediated by two receptors TNFR I and TNFR2. Its activity can be inhibited hy neutralizing monoclonal antibodies or soluble TNF receptors. The inhibition of its biological activities using anti TNF-α antibodies represents an approved strategy for the treatment nf various diseases like cancer, autoimmune diseases, inflammations etc. The involvemenl of TNF-α cytokine in the various types of diseases provide thc therapeutic rationale for the development of TNF-α antagonist.A large numher of natural and synthetic compounds are currently being investigated for TNF-α inhibitory activity. Since the synthetic molecules arc always associated with their side effects hence it is beneficial to develop the natural strategies as the alternative sources. There arc many medicinal plants which are traditionally used for the treatment of the diseases associated with TNF-α inhibition. Hence, in this review article we make an approach to provide a platform for the development of TNF-α antagonist from natural resources.
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://ihbt.csircentral.net/1309/1/82._Therapeutic.pdf
Verma , Praveen Kumar and Bala , Manju and Kumar, Neeraj and Singh , Bikram (2012) Therapeutic Potential of Natural Products from Terrestrial Plants as TNF-α Antagonist. Journal of Current Topics in Medicinal Chemistry, 12. pp. 1422-1435.
 
Relation http://ihbt.csircentral.net/1309/