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Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives

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Title Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole
containing phthalimide derivatives
 
Creator Shunmugam , Nagarajan
Majumder, Syamantak
Sharma, Upendra Kumar
Rajendran, Saranya
Kumar, Neeraj
Chatterjee, Suvro
Singh , Bikram
 
Subject Natural Product Chemistry
 
Description Benzothiazole and benzimidazole containing phthalimide derivatives (NK037, NK041, NK042, NK0139A
and NK0148) have been synthesized and their anti-angiogenic activity was evaluated using ex vivo egg
yolk angiogenesis model. A comparative study with pure thalidomide (NKTA) has also been performed to
describe the efficacy of these derivatives in blocking angiogenesis. NK037, NK041 and NK042 were
equally potent in blocking egg yolk angiogenesis and the anti-angiogenesis effect was higher than NKTA
suggesting the efficacy of these three derivatives in blocking angiogenesis when compare to control.
Other two derivatives NK0139A and NK0148 showed effect less than NKTA and stronger than control
in ex vivo angiogenesis.
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://ihbt.csircentral.net/1318/1/99_Synthesis.pdf
Shunmugam , Nagarajan and Majumder, Syamantak and Sharma, Upendra Kumar and Rajendran, Saranya and Kumar, Neeraj and Chatterjee, Suvro and Singh , Bikram (2013) Synthesis and anti-angiogenic activity of benzothiazole, benzimidazole containing phthalimide derivatives. Journal Bioorganic & Medicinal Chemistry Letters, 23. pp. 287-290.
 
Relation http://ihbt.csircentral.net/1318/