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Development of stevioside Pluronic-F-68 copolymer based PLA-nanoparticles as an antidiabetic nanomedicine

IR@CSIR-IHBT

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Title Development of stevioside Pluronic-F-68 copolymer based PLA-nanoparticles as
an antidiabetic nanomedicine
 
Creator Barwala,, Indu
Sood, Anil
Sharma, Mohit
Singh , Bikram
Yadav, Subhash C.
 
Subject Plant sciences
Plant Biotechnology
 
Description Stevioside (FDA approved nontoxic natural non-caloric sweetener) has been reported to have very good
antidiabetic potential but its use as therapeutic drug is restricted in human due to its deprived intestinal
absorption and poor bioavailability. We have nano-bioconjugated this molecule on biodegradable
Pluronic-F-68 copolymer based PLA nanoparticles by nanoprecipitation method (spherical, size range
110–130 nm) to overcome deprived intestinal absorption and to enhance the bioavailability. The drug
loading calculated by the standard calibrated HPLC was 16.32
±
4% (w/w). The in vitro release study
showed the initial burst followed by the sustained release. The half release and complete release were
observed on 25
±
4 h and 200
±
10 h respectively. This newly formulated nanostevioside showed very
high potential to be used as antidiabetic nanomedicine for safe and effective use in vivo.
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://ihbt.csircentral.net/1319/1/100_Deveopment_of_stevioside.pdf
Barwala,, Indu and Sood, Anil and Sharma, Mohit and Singh , Bikram and Yadav, Subhash C. (2013) Development of stevioside Pluronic-F-68 copolymer based PLA-nanoparticles as an antidiabetic nanomedicine. Journal of Colloids and Surfaces B: Biointerfaces, 101. pp. 510-516.
 
Relation http://ihbt.csircentral.net/1319/