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Immunomodulatory active steroidal saponins from Asparagus racemosus

IR@CSIR-IHBT

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Title Immunomodulatory active steroidal saponins from Asparagus
racemosus
 
Creator Sharma, Upendra
Kumar, Neeraj
Singh , Bikram
Munshi, Renuka K.
Bhalerao, Supriya
 
Subject Natural Product Chemistry
 
Description Asparagus racemosus is used in the Indian
traditional system of medicine for improving the general
state of health and stress-related immune disorders. Most of
the synthetic chemotherapeutic agents available today are
immunosuppressants and exert variety of side effects. To
overcome these undesired effects of chemotherapeutic
agents, botanical-based immunomodulators are often
employed as adjuvant therapy. In the present study,
immunomodulatory activity of two steroidal saponins
shatavaroside A (1) and shatavaroside B (2), isolated from
Asparagus racemosus, have been evaluated using polymorphonuclear
leucocyte function test. The activity was
further confirmed using more sensitive assays such as
nitroblue tetrazolium, nitrous oxide, and chemiluminescence
assays. Both steroidal saponins were found active at
nano concentration (5 ng/ml) and can act as potent
immunostimulants.
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://ihbt.csircentral.net/1322/1/105_Immunomodulatory.pdf
Sharma, Upendra and Kumar, Neeraj and Singh , Bikram and Munshi, Renuka K. and Bhalerao, Supriya (2013) Immunomodulatory active steroidal saponins from Asparagus racemosus. Journal of Medicinal Chemistry Research, 22. pp. 573-579.
 
Relation http://ihbt.csircentral.net/1322/