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Biocatalysts for multicomponent Biginelli reaction: bovine serum albumin triggered waste-free synthesis of 3,4-dihydropyrimidin-2-(1H)-ones

IR@CSIR-IHBT

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Title Biocatalysts for multicomponent Biginelli reaction:
bovine serum albumin triggered waste-free synthesis
of 3,4-dihydropyrimidin-2-(1H)-ones
 
Creator Sharma , U K
Sharma, Nandini
Kumar, Rajesh
Sinha, Arun K
 
Subject Natural Product Chemistry
 
Description Bovine serum albumin (BSA) promoted simple
and efficient one-pot procedure was developed for the
direct synthesis of 3,4-dihydropyrimidin-2(1H)-ones
including potent mitotic kinesin Eg5 inhibitor monastrol
under mild reaction conditions. The catalyst recyclability
and gram scale synthesis have also been demonstrated to
enhance the practical utility of process.
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://ihbt.csircentral.net/1332/1/107_Biocatalysts.pdf
Sharma , U K and Sharma, Nandini and Kumar, Rajesh and Sinha, Arun K (2013) Biocatalysts for multicomponent Biginelli reaction: bovine serum albumin triggered waste-free synthesis of 3,4-dihydropyrimidin-2-(1H)-ones. Journal of Amino Acids, 44. pp. 1031-1037.
 
Relation http://ihbt.csircentral.net/1332/