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Zephgrabetaine: A New Betaine-type Amaryllidaceae Alkaloid from Zephyranthes grandiflora

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Title Zephgrabetaine: A New Betaine-type Amaryllidaceae Alkaloid from
Zephyranthes grandiflora
 
Creator Katocha, Deepali
Kumarb, Dharmesh
Sharma, Upendra
Kumar, Neeraj
Padwad, Yogendra S.
Lal, Brij
Singh , Bikram
 
Subject Natural Product Chemistry
 
Description Zephgrabetaine (1), a new betaine type Amaryllidaceae alkaloid, along with seven known alkaloids, lycorine, galanthine, lycoramine, hamayne,
haemanthamine, tortuosine, and ungeremine were isolated from the bulbs of Zephyranthes grandiflora and their structures elucidated by spectroscopic data
analysis. The isolated alkaloids were tested for in vitro cytotoxic activities against two cell lines, C-6 (rat glioma cells) and CHO-K1 (Chinese hamster ovary
cells). A dose dependent cytotoxic effect was exhibited by all the alkaloids on these two cancer cell lines with prominent activity of lycorine and
haemanthamine.
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://ihbt.csircentral.net/1337/1/105_Zephgrabetaine_A_new.pdf
Katocha, Deepali and Kumarb, Dharmesh and Sharma, Upendra and Kumar, Neeraj and Padwad, Yogendra S. and Lal, Brij and Singh , Bikram (2013) Zephgrabetaine: A New Betaine-type Amaryllidaceae Alkaloid from Zephyranthes grandiflora. Journal of Natural Product Communications, 8 (2). pp. 161-164.
 
Relation http://ihbt.csircentral.net/1337/