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Synthesis and SAR investigation of natural phenylpropenederived methoxylated cinnamaldehydes and their novel Schiff bases as potent antimicrobial and antioxidant agents

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Title Synthesis and SAR investigation of natural phenylpropenederived
methoxylated cinnamaldehydes and their novel Schiff
bases as potent antimicrobial and antioxidant agents
 
Creator Sharma , U K
Sood, Swati
Sharma, Nandini
Rahi, P
Kumar, Rakesh
Sinha, Arun K
 
Subject Plant sciences
 
Description A series of cinnamyl compounds were synthesized
from abundantly available methoxylated phenylpropenes
and evaluated for their antimicrobial activity by the
broth microdilution method against fourteen opportunistic
bacterial and fungal human pathogens. Structure–activity
relationship studies indicated that methylenedioxy cinnamaldehyde
exhibited promising broad-spectrum activity
against the tested microorganisms and hence was used as a
lead structure to synthesize novel Schiff bases/heterocyclic
compounds (23–33) under microwave irradiation. Out of
these, thiazole-based Schiff bases have shown promising
antibacterial activity against B. subtilis (26; MIC 0.12 mM),
M. luteus (27; MIC 0.20 mM), and S. aureus (27; MIC
0.20 mM). Also, the compounds 23–33 were investigated for
in vitro antioxidant activity using DPPH• assay where
compound 28 showed a maximum of 80.71 % inhibition.
 
Date 2013
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://ihbt.csircentral.net/1347/1/134_Synthesis_and_SAR.pdf
Sharma , U K and Sood, Swati and Sharma, Nandini and Rahi, P and Kumar, Rakesh and Sinha, Arun K (2013) Synthesis and SAR investigation of natural phenylpropenederived methoxylated cinnamaldehydes and their novel Schiff bases as potent antimicrobial and antioxidant agents. Medicinal Chemistry Research .
 
Relation http://ihbt.csircentral.net/1347/