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Environmental sensing and signal transduction pathways regulating morphopathogenic detrminants of Candida albicans

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Title Environmental sensing and signal transduction pathways regulating morphopathogenic detrminants of Candida albicans
 
Creator Biswas, Subhrajit
Van Dijck, Patrick
Datta, Asis
 
Subject Signal Transduction Pathways
Candida albicans
Environmental Sensing
Morphopathogenic Determinants
 
Description Opportunistic fungal pathogens, such as Candida albicans,
are found in the normal gastrointestinal flora and the oral
mucosa of most healthy humans. However, in immunocompromised patients, bloodstream infections often cause death, despite the use of antifungal therapies (152). The underlying
molecular mechanisms for survival inside the human body and
adaptation to various environments are probably distinct but
overlapping. Dietary factors, such as an excess of or deficiency
in certain nutrients, may alter the endogenous microbial flora.
Mechanical factors, such as trauma or occlusive injury, can also
alter the microenvironment, deplete the system of “friendly
bacteria,” and enable the pathogenic fungus to take over. Immunocompromised or immunosuppressed persons, including
AIDS patients, neonates, and transplant recipients, are also
particularly susceptible to fungal infections.
Recent studies of the GlcNAc signaling pathway in the laboratory of
A.D. have been supported by the Department of Biotechnology, India.
Original work performed in the laboratory of P.V.D. was supported by
grants from the Research Fund of Flanders (G.0242.04) and from the
European Commission, Marie-Curie RTN Project CanTrain (MRTN-CT-2004-512841).
 
Date 2013-11-05T05:36:46Z
2013-11-05T05:36:46Z
2007
May 2007
 
Type Article
 
Identifier Microbiol. Mol. Biol. Reviews, 71(2): 348-376
http://hdl.handle.net/123456789/64
 
Language en
 
Publisher American Society for Microbiology