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Downregulation of terpenoid indole alkaloid biosynthetic pathway by low temperature and cloning of a AP2 type C-repeat binding factor (CBF) from Catharanthus roseus (L). G. Don

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Title Downregulation of terpenoid indole alkaloid biosynthetic pathway by low temperature and cloning of a AP2 type C-repeat binding factor (CBF) from Catharanthus roseus (L). G. Don
 
Creator Dutta, Ajaswrata
Sen, Jayanti
Deswal, Renu
 
Subject Abiotic stress
AP2/ERF
Catharanthus roseus
C-repeat binding factor
TIA and primary biosynthetic pathway genes
TIA accumulation
 
Description Plants produce secondary metabolites in response to various external signals. Coordinated transcriptional control of biosynthetic genes emerges as a major
mechanism dictating the accumulation of secondary
metabolites in plant cells. However, information about
stress regulation of secondary metabolites and the molecular mechanisms regulating these specialized pathways are
poorly understood. Here, we show that terpenoid indole
alkaloid (TIA) biosynthetic pathway is differentially regulated in response to different abiotic stresses in Catharanthus roseus, a model medicinal plant producing important
anticancer and antihypertensive drugs. Semiquantitative
RT-PCR analysis of TIA and related primary pathway
genes in response to dehydration, low temperature, salinity,
UV-light and wounding revealed their negative regulation
in response to low temperature. HPLC analysis further
supports the notion that TIA biosynthetic pathway is negatively controlled by low temperature stress.
This work was supported by the Department of Biotechnology, Government of India. AD pay her tribute and
dedicate this paper to Dr Jayanti Sen, who unfortunately passed away
before this work was published.
 
Date 2013-11-05T05:43:51Z
2013-11-05T05:43:51Z
2007
7 May 2007
 
Type Article
 
Identifier Plant Cell Reports, 26: 1869-1878
http://hdl.handle.net/123456789/65
 
Language en
 
Publisher Springer