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Role of α-tocopherol in cellular signaling: α-tocopherol inhibits stress-induced mitogen activated protein kinase activation

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Title Role of α-tocopherol in cellular signaling: α-tocopherol inhibits stress-induced mitogen activated protein kinase activation
 
Creator Hyun, Tae Kyung
Kumar, Kundan
Rao, Kudupudi Prabhakara
Sinha, Alok Krishna
Roitsch, Thomas
 
Subject a-Tocopherol
MAPKs
Non-antioxidant
Stress
E-Fol
 
Description Tocopherols belong to the plant-derived poly phenolic compounds known for antioxidant functions in plants and animals. Activation of mitogen-activated protein kinases (MAPK) is a common reaction of plant cells in defense-related signal transduction pathways. We report a novel non-antioxidant function of α-tocopherol in higher plants linking the physiological role of tocopherol with stress signalling pathways. Pre-incubation of a low concentration of 50 μM α-tocopherol negatively interferes with MAPK activation in elicitor-treated tobacco BY2 suspension culture cells and wounded tobacco leaves, whereas pre-incubated BY2 cells with α-tocopherol phosphate did not show the inhibitory effect on stimuli-induced MAPK activation. The decreased MAPK activity was neither due to a direct inhibitory effect of α-tocopherol nor due to the induction of an inhibitory or inactivating activity directly affecting MAPK activity. The data support that the target of α-tocopherol negatively regulates an upstream component of the signaling pathways that leads to stress dependent MAPK activation.
T.K.H. acknowledges the fellowship provided
by DAAD and Graduierten Kolleg 1342. K.K. and K.P.R. are grateful
for fellowships provided by DST-DAAD and UGC, India. A.K.S. and
T.R. are grateful for funding from the joint Indo-German DAAD-DST
project (No. D/07/13475 and DST/INT/DAAD/P-165/2007).
 
Date 2014-04-28T05:41:28Z
2014-04-28T05:41:28Z
2011
2 October 2010
 
Type Article
 
Identifier Plant Biotechnology Reports, 5(1): 19-25
http://hdl.handle.net/123456789/191
 
Language en
 
Publisher Springer Science