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Structure and regulatory networks of WD40 protein in plants

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Title Structure and regulatory networks of WD40 protein in plants
 
Creator Mishra, Awdhesh Kumar
Puranik, Swati
Prasad, Manoj
 
Subject WD40 protein
DWD box
β-propeller
Scaffold
CLR4 ligase
 
Description Plants have been gifted with intricate regulatory networks to carry on with their sessile life form. Often such networks involve delicate association between various proteins. The WD40 proteins, which are present abundantly in several eukaryotes, act as scaffolding molecules assisting proper activity of other proteins. They comprise several stretches of 44–60 amino acid residues and often terminate with a WD dipeptide. They function in several cellular, metabolic and molecular pathways, biologically playing important roles in plant development and also during stress signaling. Moreover, some WD40 (named DWD) proteins also function as substrate receptors in Cullin4 RING dependent E3 ubiquitin ligase mediated proteosomal degradation and DNA damage repair mechanism. In this review, we have discussed the various aspects of these proteins that affect their highly diversified functions in plants.
Grateful thanks are due to the Director, National
Institute of Plant Genome Research (NIPGR), New Delhi, India for
providing facilities. The authors work in this area was supported by
NIPGR core grant and Department of Biotechnology (DBT), Govt. of
India. Mr Awdhesh Kumar Mishra and Ms Swati Puranik acknowledge
the fellowships form the Council of Scientific and Industrial Research,
and NIPGR, New Delhi, respectively.
 
Date 2015-10-27T09:26:05Z
2015-10-27T09:26:05Z
2012
 
Type Article
 
Identifier J. Plant Biochem. Biotechnol., 21: S32-S39
0974-1275
http://link.springer.com/article/10.1007%2Fs13562-012-0134-1
http://172.16.0.77:8080/jspui/handle/123456789/263
 
Language en_US
 
Publisher Springer