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Comparative analyses of nuclear proteome: extending its function

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Title Comparative analyses of nuclear proteome: extending its function
 
Creator Narula, Kanika
Datta, Asis
Chakraborty, Niranjan
Chakraborty, Subhra
 
Subject nucleus
comparative proteome
organeller proteome
plant
nuclear proteins
 
Description Accepted date: 30 March 2013
Organeller proteomics is an emerging technology that is critical in determining the cellular signal transduction pathways. Nucleus, the regulatory hub of the eukaryotic cell is a dynamic system and a repository of various macromolecules that serve as modulators of such signaling that dictate cell fate decisions. Nuclear proteins (NPs) are predicted to comprise about 10-20% of the total cellular proteins, suggesting the involvement of the nucleus in a number of diverse functions. Indeed, NPs constitute a highly organized but complex network that plays diverse roles during development and physiological processes. In plants, relatively little is known about the nature of the molecular components and mechanisms involved in coordinating NP synthesis, their action and function. Proteomic study hold promise to understand the molecular basis of nuclear function using an unbiased comparative and differential approach. We identified a few hundred proteins that include classical and non-canonical nuclear components presumably associated with variety of cellular functions impinging on the complexity of nuclear proteome. Here, we review the nuclear proteome based on our own findings, available literature, and databases focusing on detailed comparative analysis of NPs and their functions in order to understand how plant nucleus works. The review also shed light on the current status of plant nuclear proteome and discusses the future prospect.
This research work was supported by grants from the Department
of Biotechnology (DBT), Ministry of Science and Technology,
Govt. of India (grant no. BT/PR10796/BRB/10/621/2008) and the
National Institute of Plant Genome Research, India to S.C. K.N. is
the recipient of pre-doctoral fellowship from Council of Scientific
and Industrial Research (CSIR), Govt. of India. Authors thank Mr.
Jasbeer Singh for illustrations and graphical representation in the
manuscript.
 
Date 2015-11-09T07:16:40Z
2015-11-09T07:16:40Z
2013
 
Type Article
 
Identifier Front. Plant Sc., 4: 100
1664-462X
http://172.16.0.77:8080/jspui/handle/123456789/349
http://journal.frontiersin.org/article/10.3389/fpls.2013.00100/abstract
10.3389/fpls.2013.00100
 
Language en_US
 
Publisher Frontiers