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DUF581 is plant specific FCS-like zinc finger involved in protein-protein interaction

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Title DUF581 is plant specific FCS-like zinc finger involved in protein-protein interaction
 
Creator K, Muhammed Jamsheer
Laxmi, Ashverya
 
Subject DUF581
Zinc Finger
Protein-Protein Interaction
 
Description Accepted date: May 11, 2014
Zinc fingers are a ubiquitous class of protein domain with considerable variation in structure and function. Zf-FCS is a highly diverged group of C2-C2 zinc finger which is present in animals, prokaryotes and viruses, but not in plants. In this study we identified that a plant specific domain of unknown function, DUF581 is a zf-FCS type zinc finger. Based on HMM-HMM comparison and signature motif similarity we named this domain as FCS-Like Zinc finger (FLZ) domain. A genome wide survey identified that FLZ domain containing genes are bryophytic in origin and this gene family is expanded in spermatophytes. Expression analysis of selected FLZ gene family members of A. thaliana identified an overlapping expression pattern suggesting a possible redundancy in their function. Unlike the zf-FCS domain, the FLZ domain found to be highly conserved in sequence and structure. Using a combination of bioinformatic and protein-protein interaction tools, we identified that FLZ domain is involved in protein-protein interaction.
This work was financially supported by the National Institute of Plant Genome Research (NIPGR) core grant and University Grants Commission, Government of India (research fellowship to MJK). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
 
Date 2015-12-17T06:40:45Z
2015-12-17T06:40:45Z
2014
 
Type Article
 
Identifier PLoS One, 9(6): e99074
1932-6203
http://172.16.0.77:8080/jspui/handle/123456789/421
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099074
10.1371/journal.pone.0099074
 
Language en_US
 
Publisher PLOS