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Comprehensive genome-wide analysis reveals different classes of enigmatic old yellow enzyme in fungi

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Title Comprehensive genome-wide analysis reveals different classes of enigmatic old yellow enzyme in fungi
 
Creator Nizam, Shadab
Verma, Sandhya
Borah, Nilam Nayan
Gazara, Rajesh Kumar
Verma, Praveen K.
 
Subject FUNGAL GENOMICS
FUNGAL BIOLOGY
 
Description Accepted date: 17 January 2014
In this study, we systematically identify Old Yellow Enzymes (OYEs) from a diverse range of economically
important fungi representing different ecology and lifestyle. Using active site residues and sequence
alignments, we present a classification for these proteins into three distinct classes including a novel class
(Class III) and assign names to sequences. Our in-depth phylogenetic analysis suggests a complex history of
lineage-specific expansion and contraction for the OYE gene family in fungi. Comparative analyses reveal
remarkable diversity in the number and classes of OYE among fungi. Quantitative real-time PCR
(qRT-PCR) of Ascochyta rabiei OYEs indicates differential expression of OYE genes during oxidative stress
and plant infection. This study shows relationship of OYE with fungal ecology and lifestyle, and provides a
foundation for future functional analysis and characterization of OYE gene family.
We gratefully acknowledge a research grant from Department of Biotechnology,
Government of India (File No: BT/PR10605/PBD/16/791/2008) and a core grant from
National Institute of Plant Genome Research, New Delhi, India for funding this work. We
are also thankful to the Director, National Institute of Plant Genome Research for providing
facilities and help during this study. SN, SV and NNB acknowledge University Grants
Commission, Council of Scientific and Industrial Research, and Department of
Biotechnology, Government of India, respectively for their fellowships.
 
Date 2015-12-22T06:19:15Z
2015-12-22T06:19:15Z
2014
 
Type Article
 
Identifier Scientific Reports, 4: 4013
2045-2322
http://172.16.0.77:8080/jspui/handle/123456789/440
http://www.nature.com/articles/srep04013
10.1038/srep04013
 
Language en_US
 
Publisher Nature Publishing Group