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Regulation of MAP kinase signaling cascade by microRNAs in Oryza sativa

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Title Regulation of MAP kinase signaling cascade by microRNAs in Oryza sativa
 
Creator Raghuram, Badmi
Sheikh, Arsheed Hussain
Sinha, Alok Krishna
 
Subject MAP kinase
microRNA
signaling
stress
rice
regulation
 
Description Accepted date: 1 July 2014
Mitogen activated protein kinase (MAPK) pathway is one of the most conserved signaling cascade in plants regulating a plethora of cellular processes including normal growth and development, abiotic and biotic stress responses. The perception of external cues triggers the phosphorylation of three tier MAPKKK-MAPKK-MAPK cascade which finally modifies a downstream substrate thereby regulating the cellular processes. Whereas, the transcription regulation by MAPKs, mediated through their substrates is well studied in plants, the transcription and post-transcriptional regulation of the MAPK genes are poorly understood. Previous studies from the animals systems suggested the miRNAs regulate the post-transcriptional regulation of MAPK transcripts. Here we attempt to unravel the post-transcriptional regulation of MAPKs by miRNAs in model crop plant Oryza sativa. Using in silico tools, we predict the miRNAs for 98 out of 99 MAPK transcripts. The predicted miRNAs were validated for the biological relevance of their function. The inverse correlation between relative transcript levels between the MAPKs and their predicted miRNAs validated the in silico prediction. Taken together, this report demonstrates the significance of miRNAs in regulation of the MAPK pathway in plants with a new direction to study the plant signaling molecules.
BR kindly acknowledges Department of Biotechnology, Govt.
of India while AS thanks Council of Scientific and Industrial
Research, India, for financial support. The work is supported by
the core grant of National Institute of Plant Genome Research
from Department of Biotechnology, Govt. of India
 
Date 2015-12-22T06:46:30Z
2015-12-22T06:46:30Z
2014
 
Type Article
 
Identifier Plant Signal. Behav., 9(10): e972130
http://172.16.0.77:8080/jspui/handle/123456789/442
http://www.tandfonline.com/doi/full/10.4161/psb.29804
10.4161/psb.29804
 
Language en_US
 
Publisher Taylor & Francis Group