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Molecular recognition by the KIX domain and its role in gene regulation

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Title Molecular recognition by the KIX domain and its role in gene regulation
 
Creator Thakur, Jitendra K.
Yadav, Archana
Yadav, Gitanjali
 
Subject KIX domains
kinase-inducible domain interacting
 
Description Accepted date: October 24, 2013
The kinase-inducible domain interacting (KIX) domain is a highly conserved independently folding three-helix bundle that serves as a docking site for transcription factors, whereupon promoter activation and target specificity are achieved during gene regulation. This docking event is a harbinger of an intricate multi-protein assembly at the transcriptional apparatus and is regulated in a highly precise manner in view of the critical role it plays in multiple cellular processes. KIX domains have been characterized in transcriptional coactivators such as p300/CREB-binding protein and mediator of RNA polymerase II transcription subunit 15, and even recQ protein-like 5 helicases in various organisms. Their targets are often intrinsically disordered regions within the transactivation domains of transcription factors that attain stable secondary structure only upon complexation with KIX. In this article, we review the KIX domain in terms of its sequence and structure and present the various implications of its ability to act as a transcriptional switch, the mechanistic basis of molecular recognition by KIX, its binding specificity, target promiscuity, combinatorial potential and unique mode of regulation via allostery. We also discuss the possible roles of KIX domains in plants and hope that this review will accelerate scientific interest in KIX and pave the way for novel avenues of research on this critical domain.
Innovative Young Biotechnologist Award (IYBA) grant
from the Department of Biotechnology (DBT),
Government of India, awarded to [BT/BI/12/045/2008 to
J.K.T. and BT/BI/12/040/2005 to G.Y.]; Research grant
[BT/PR14519/BRB/10/869/2010 from DBT to J.K.T.];
Recipient of the junior research fellowship (JRF) of the
University Grants Commission, Government of India
(to A.V.). Funding for open access charge: National
Institute of Plant Genome Research.
 
Date 2015-12-29T10:41:31Z
2015-12-29T10:41:31Z
2014
 
Type Article
 
Identifier Nucl. Acids Res., 42(4): 2112-2125
1362-4962
http://172.16.0.77:8080/jspui/handle/123456789/469
http://nar.oxfordjournals.org/content/42/4/2112
10.1093/nar/gkt1147
 
Language en_US
 
Publisher Oxford University Press