Record Details

Role of proline and pyrroline-5-carboxylate metabolism in plant defense against invading pathogens

NIPGR Digital Knowledge Repository (NDKR)

View Archive Info
 
 
Field Value
 
Title Role of proline and pyrroline-5-carboxylate metabolism in plant defense against invading pathogens
 
Creator Qamar, Aarzoo
Mysore, Kirankumar S.
Senthil-Kumar, Muthappa
 
Subject P5C
proline
ROS
oxidative burst
hypersensitive response
plant defense
non-host resistance
 
Description Accepted date: 22 June 2015
Pyrroline-5-carboxylate (P5C) is an intermediate product of both proline biosynthesis and catabolism. Recent evidences indicate that proline-P5C metabolism is tightly regulated in plants, especially during pathogen infection and abiotic stress. However, role of P5C and its metabolism in plants has not yet been fully understood. Studies indicate that P5C synthesized in mitochondria has a role in both resistance (R)-gene-mediated and non-host resistance against invading pathogens. Proline dehydrogenase and delta-ornithine amino transferase-encoding genes, both involved in P5C synthesis in mitochondria are implicated in defense response of Nicotiana benthamiana and Arabidopsis thaliana against bacterial pathogens. Such defense response is proposed to involve salicylic acid-dependent pathway, reactive oxygen species (ROS) and hypersensitive response (HR)-associated cell death. Recently HR, a form of programmed cell death (PCD), has been proposed to be induced by changes in mitochondrial P5C synthesis or the increase in P5C levels per se in plants inoculated with either a host pathogen carrying suitable avirulent (Avr) gene or a non-host pathogen. Consistently, A. thaliana mutant plants deficient in P5C catabolism showed HR like cell death when grown in external P5C or proline supplemented medium. Similarly, yeast and plant cells under oxidative stress were shown to increase ROS production and PCD due to increase in P5C levels. Similar mechanism has also been reported as one of the triggers for apoptosis in mammalian cells. This review critically analyzes results from various studies and enumerates the pathways for regulation of P5C levels in the plant cell, especially in mitochondria, during pathogen infection. Further, mechanisms regulating P5C- mediated defense responses, namely HR are outlined. This review also provides new insights into the differential role of proline-P5C metabolism in plants exposed to pathogen infection.
This work was supported by the core funding to MS-K’s lab from
National Institute of Plant Genome Research, New Delhi. AQ
thanks the University Grant Commission (UGC), New Delhi for
a junior research fellowship award (Ref. No. 23/12/2012(ii) EU-
V). Authors also thank Mr. Mehanathan Muthamilarasan and Dr.
Prachi Pandey for critical reading of the manuscript.
 
Date 2016-01-21T08:09:30Z
2016-01-21T08:09:30Z
2015
 
Type Article
 
Identifier Front. Plant Sc., 6: 503
1664-462X
http://172.16.0.77:8080/jspui/handle/123456789/564
http://journal.frontiersin.org/article/10.3389/fpls.2015.00503/abstract
10.3389/fpls.2015.00503
 
Language en_US
 
Publisher Frontiers Media S.A.