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Importance of mediator complex in the regulation and integration of diverse signaling pathways in plants

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Title Importance of mediator complex in the regulation and integration of diverse signaling pathways in plants
 
Creator Samanta, Subhasis
Thakur, Jitendra K.
 
Subject transcription
RNA polymerase II
mediator complex
development
defense signaling
abiotic stress
Arabidopsis
rice
 
Description Accepted date: 04 September 2015
Basic transcriptional machinery in eukaryotes is assisted by a number of cofactors, which either increase or decrease the rate of transcription. Mediator complex is one such cofactor, and recently has drawn a lot of interest because of its integrative power to converge different signaling pathways before channeling the transcription instructions to the RNA polymerase II machinery. Like yeast and metazoans, plants do possess the Mediator complex across the kingdom, and its isolation and subunit analyses have been reported from the model plant, Arabidopsis. Genetic, and molecular analyses have unraveled important regulatory roles of Mediator subunits at every stage of plant life cycle starting from flowering to embryo and organ development, to even size determination. It also contributes immensely to the survival of plants against different environmental vagaries by the timely activation of its resistance mechanisms. Here, we have provided an overview of plant Mediator complex starting from its discovery to regulation of stoichiometry of its subunits. We have also reviewed involvement of different Mediator subunits in different processes and pathways including defense response pathways evoked by diverse biotic cues. Wherever possible, attempts have been made to provide mechanistic insight of Mediator's involvement in these processes.
Research in our lab is funded by NIPGR core grant and grants (IYBA grant BT/BI/12/045/2008 and BT/PR14519/BRB/10/869/2010) from Department of Biotechnology (DBT), Ministry of Science and Technology, Government of India. SS acknowledges Research Associate Fellowship from DBT and Short-Term Research Fellowship from NIPGR. We would like to thank Dr. Pradipto Mukhopadhyay for his comments and suggestions which helped to improve the manuscript.
 
Date 2016-01-21T09:53:12Z
2016-01-21T09:53:12Z
2015
 
Type Article
 
Identifier Front. Plant Sc., 6: 757
1664-462X
http://172.16.0.77:8080/jspui/handle/123456789/571
http://journal.frontiersin.org/article/10.3389/fpls.2015.00757/abstract
10.3389/fpls.2015.00757
 
Language en_US
 
Publisher Frontiers Media S.A.