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Ebola virus disease: Biology, diagnosis, treatment and prevention of epidemics

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Title Ebola virus disease: Biology, diagnosis, treatment and prevention of epidemics
 
Creator Kumar, Sushil
Kumari, Renu
Pandey, Richa
Sharma, Vishakha
 
Subject Anti-Ebola Therapeutics/Vaccines
Cytokine Storm
Ebolavirus Disease
Ebola Genetics
Filovirus
Repurposed Drugs
 
Description Accepted date: 20 October 2016
Ebola virus disease (EVD) is a highly lethal contagious disease caused by the negative RNA strand Ebola virus. Reservoired in wild forest animals of Africa, Ebola virus infects humans that come in direct contact of diseased animals and outbreaks of EVD result from person to person spread of infection. A recent EVD outbreak in West Africa has killed several thousand persons. Since Ebola infection will persist in animals, EVD epidemics are expected to continue to occur in future. Infected travellers from Africa can initiate/import outbreaks in countries of other continents. This review describes the properties of the Ebola virus and EVD, the ongoing attempts to develop diagnostics, vaccines and medicines for prevention and cure of EVD and the supportive care that saves some EVD patients. Also discussed are measures that can stop and prevent EVD outbreaks. Need for inclusion of EVD in the education, research, drug and medical equipment manufacturing programmes, of the densly populated countries such as India, is emphasised.
Grateful thanks are due towards Indian National
Science Academy for the grant of an INSA emeritus
scientistship to SK and to Director of National Institute
of Plant Genome Research and Director of Indian
Institute of Chemical Technology for facilities, and to
the virologists AC Banerjea of National Institute of
Immunology and RK Saxena of South-Asian
University for reading the draft of the manuscript and
making useful suggestions for its improvement.
 
Date 2017-05-22T10:17:23Z
2017-05-22T10:17:23Z
2017
 
Type Article
 
Identifier Proceedings of the Indian National Science Academy, 83(1): 103-149
2454-9983
http://59.163.192.83:8080/jspui/handle/123456789/747
http://www.insajournals.in/insaj/index.php/proceedings/article/view/291
10.16943/ptinsa/2017/41286
 
Language en_US
 
Publisher Indian National Science Academy