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Emerging functions of multi-protein complex Mediator with special emphasis on plants

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Title Emerging functions of multi-protein complex Mediator with special emphasis on plants
 
Creator Malik, Naveen
Agarwal, Pinky
Tyagi, Akhilesh K.
 
Subject Development
Mediator
plant
stress
transcription
 
Description Accepted: 28 April 2017
Mediator is a multi-subunit protein complex which is involved in transcriptional regulation in yeast and other eukaryotes. As a co-activator, it connects information from transcriptional activators/repressors to transcriptional machinery including RNA polymerase II and general transcription factors. It is not only involved in transcription initiation but also has important roles to play in transcription elongation and termination. Functional attributes of different Mediator subunits have been largely defined in yeast and mammalian systems earlier, while such studies in plants have gained momentum recently. Mediator regulates various processes related to plant development and is also involved in biotic and abiotic stress response. Thus, plant Mediator, like yeast and mammalian Mediator complex, is indispensable for plant growth and survival. Interaction of its multiple subunits with other regulatory proteins and their ectopic expression or knockdown in model plant like Arabidopsis and certain crop plants are paving the way to biochemical analysis and unravel molecular mechanisms of action of Mediator in plants.
The authors sincerely acknowledge the financial support provided
by NIPGR, New Delhi, and Department of
Biotechnology (DBT), Government of India.
 
Date 2017-05-23T09:36:28Z
2017-05-23T09:36:28Z
2017
 
Type Article
 
Identifier Critical Reviews in Biochemistry and Molecular Biology, 52(5): 475-502
1549-7798
http://59.163.192.83:8080/jspui/handle/123456789/748
http://www.tandfonline.com/doi/full/10.1080/10409238.2017.1325830
http://dx.doi.org/10.1080/10409238.2017.1325830
 
Language en_US
 
Publisher Taylor & Francis Group