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Geminiviruses and plant hosts: a closer examination of the molecular arms race

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Title Geminiviruses and plant hosts: a closer examination of the molecular arms race
 
Creator Ramesh, Shunmugiah V.
Sahu, Pranav P.
Prasad, Manoj
Praveen, Shelly
Pappu, Hanu R.
 
Subject geminivirus
plant-virus interactions
cellular reprogramming
small non-coding RNAs
viral suppressors
 
Description Accepted date: 6 September 2017
Geminiviruses are plant-infecting viruses characterized by a single-stranded DNA (ssDNA) genome. Geminivirus-derived proteins are multifunctional and effective regulators in modulating the host cellular processes resulting in successful infection. Virus-host interactions result in changes in host gene expression patterns, reprogram plant signaling controls, disrupt central cellular metabolic pathways, impair plant's defense system, and effectively evade RNA silencing response leading to host susceptibility. This review summarizes what is known about the cellular processes in the continuing tug of war between geminiviruses and their plant hosts at the molecular level. In addition, implications for engineered resistance to geminivirus infection in the context of a greater understanding of the molecular processes are also discussed. Finally, the prospect of employing geminivirus-based vectors in plant genome engineering and the emergence of powerful genome editing tools to confer geminivirus resistance are highlighted to complete the perspective on geminivirus-plant molecular interactions.
 
Date 2017-09-18T06:52:39Z
2017-09-18T06:52:39Z
2017
 
Type Article
 
Identifier Viruses, 9(9): 256
1999-4915
http://223.31.159.10:8080/jspui/handle/123456789/791
http://www.mdpi.com/1999-4915/9/9/256
10.3390/v9090256
 
Publisher MDPI AG