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Computer-aided biotechnology: from immuno-informatics to reverse vaccinology.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Computer-aided biotechnology: from immuno-informatics to reverse vaccinology.
 
Creator Vivona, Sandro
Gardy, Jennifer L
Ramachandran, Srinivasan
Brinkman, Fiona S L
Raghava, G.P.S.
Flower, Darren R
Filippini, Francesco
 
Subject QR Microbiology
 
Description Genome sequences from many organisms, including humans, have been completed, and high-throughput analyses have produced burgeoning volumes of 'omics' data. Bioinformatics is crucial for the management and analysis of such data and is increasingly used to accelerate progress in a wide variety of large-scale and object-specific functional analyses. Refined algorithms enable biotechnologists to follow 'computer-aided strategies' based on experiments driven by high-confidence predictions. In order to address compound problems, current efforts in immuno-informatics and reverse vaccinology are aimed at developing and tuning integrative approaches and user-friendly, automated bioinformatics environments. This will herald a move to 'computer-aided biotechnology': smart projects in which time-consuming and expensive large-scale experimental approaches are progressively replaced by prediction-driven investigations.
 
Publisher Elsevier Science
 
Date 2008-04
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/43/1/raghava2008.1
Vivona, Sandro and Gardy, Jennifer L and Ramachandran, Srinivasan and Brinkman, Fiona S L and Raghava, G.P.S. and Flower, Darren R and Filippini, Francesco (2008) Computer-aided biotechnology: from immuno-informatics to reverse vaccinology. Trends in biotechnology, 26 (4). pp. 190-200. ISSN 0167-7799
 
Relation http://www.sciencedirect.com/science/article/pii/S0167779908000504
http://crdd.osdd.net/open/43/