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Peptide mimotopes as prototypic templates of broad-spectrum surrogates of carbohydrate antigens for cancer vaccination.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Peptide mimotopes as prototypic templates of broad-spectrum surrogates of carbohydrate antigens for cancer vaccination.
 
Creator Pashov, Anastas
Monzavi-Karbassi, Behjatolah
Raghava, G.P.S.
Kieber-Emmons, Thomas
 
Subject QR Microbiology
 
Description Mechanisms of broad cross-protection, as seen in viral infection and also applied to vaccines, emphasize preexisting antibodies, CD8+ memory T cells, and accelerated B-cell responses reactive with conserved regions in antigens. Another practical application to induce broad-spectrum responses is making use of multispecific antigen recognition by antibodies and T cells. Antibody polyreactivity can be related to the capacity of the antigen-combining site to accommodate a number of different small epitopes or to attain different conformations. A better understanding of the functionality of molecular interactions with graded specificity might help the design of polyreactive immunogens inducing antibody responses to a predefined set of target antigens. We have found this approach useful in targeting tumor-associated carbohydrate antigens in cancer vaccine development. Using combinatorial libraries and pharmacophore design principles, carbohydrate mimetic peptides were created that not only induce antibodies with multiple specificities, but also cellular responses that inhibit tumor growth in vivo.
 
Publisher begell house, inc.
 
Date 2007
 
Type Article
PeerReviewed
 
Relation http://www.begellhouse.com/journals/2ff21abf44b19838,68a23a5c71b568e1,67aaa1f3652775d1.html
http://crdd.osdd.net/open/51/
 
Identifier Pashov, Anastas and Monzavi-Karbassi, Behjatolah and Raghava, G.P.S. and Kieber-Emmons, Thomas (2007) Peptide mimotopes as prototypic templates of broad-spectrum surrogates of carbohydrate antigens for cancer vaccination. Critical reviews in immunology, 27 (3). pp. 247-70. ISSN 1040-8401