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Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway.
 
Creator Sharma, S
Chopra, Kanwaljit
Kulkarni, S K
Agrewala, J N
 
Subject QR180 Immunology
 
Description The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)-10.
 
Publisher Wiley
 
Date 2007-01
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/129/1/agrewala2007.pdf
Sharma, S and Chopra, Kanwaljit and Kulkarni, S K and Agrewala, J N (2007) Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway. Clinical and experimental immunology, 147 (1). pp. 155-63. ISSN 0009-9104
 
Relation http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2249.2006.03257.x/pdf
http://crdd.osdd.net/open/129/