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Enzymatic modifications of cephalosporins by cephalosporin acylase and other enzymes.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Enzymatic modifications of cephalosporins by cephalosporin acylase and other enzymes.
 
Creator Sonawane, Vijay Chintaman
 
Subject QR Microbiology
 
Description Semisynthetic cephalosporins are important antibacterials in clinical practice. Semisynthetic cephalosporins are manufactured by derivatizing 7-aminocephalosporanic acid (7-ACA) and its desacetylated form. Microbial enzymes such as D-amino acid oxidase, glutaryl-7-ACA acylase and cephalosporin esterase are being used as biocatalysts for the conversion of cephalosporin C (CEPH-C) to 7-ACA and its desacetylated derivatives. Recent developments in the field of enzymatic modifications of cephalosporin with special emphasis on group of enzymes called as cephalosporin acylase is discussed in this review. Aspects related to screening methods, isolation and purification, immobilization, molecular cloning, gene structure and expression and protein engineering of cephalosporin acylases have been covered. Topics pertaining to enzymatic modifications of cephalosporin by D-amino acid oxidase, cephalosporin methoxylase and beta-lactamase are also covered.
 
Publisher Taylor & Francis Group/Informa Healthcare
 
Date 2006
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/146/1/sonawane2006.pdf
Sonawane, Vijay Chintaman (2006) Enzymatic modifications of cephalosporins by cephalosporin acylase and other enzymes. Critical reviews in biotechnology, 26 (2). pp. 95-120. ISSN 0738-8551
 
Relation http://informahealthcare.com/doi/abs/10.1080/07388550600718630%20
http://crdd.osdd.net/open/146/