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Mechanism of drug resistance in clonally related clinical isolates of Vibrio fluvialis isolated in Kolkata, India.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Mechanism of drug resistance in clonally related clinical isolates of Vibrio fluvialis isolated in Kolkata, India.
 
Creator Srinivasan, Vijaya Bharathi
Virk, Rupinder Kaur
Kaundal, Amita
Chakraborty, Rupa
Datta, Basabjit
Ramamurthy, T
Mukhopadhyay, A K
Ghosh, Amit
 
Subject QD Chemistry
 
Description The molecular mechanisms of drug resistance in 19 strains of Vibrio fluvialis isolated from 1998 to 2002 in Kolkata, India, were investigated. Class 1 integrons were detected in eight strains, and four strains were found to carry SXT integrases. In the presence of carbonyl cyanide m-chlorophenylhydrazone or reserpine, all nalidixic acid- and ciprofloxacin-resistant strains became sensitive, suggesting that drug efflux plays a major role in quinolone resistance in V. fluvialis. It was further seen that strains which had MICs of > 25 microg/ml for nalidixic acid had a sense mutation (Ser to Ile) at position 83 of the quinolone resistance-determining region of gyrA. All except one of the integron- and SXT integrase-bearing strains belonged to the same ribotype.
 
Publisher ASM
 
Date 2006-07
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/147/1/ghosh2006.pdf
Srinivasan, Vijaya Bharathi and Virk, Rupinder Kaur and Kaundal, Amita and Chakraborty, Rupa and Datta, Basabjit and Ramamurthy, T and Mukhopadhyay, A K and Ghosh, Amit (2006) Mechanism of drug resistance in clonally related clinical isolates of Vibrio fluvialis isolated in Kolkata, India. Antimicrobial agents and chemotherapy, 50 (7). pp. 2428-32. ISSN 0066-4804
 
Relation http://aac.asm.org/content/50/7/2428.long
http://crdd.osdd.net/open/147/