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Debaryomyces hansenii, a highly osmo-tolerant and halo-tolerant yeast, maintains activated Dhog1p in the cytoplasm during its growth under severe osmotic stress.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Debaryomyces hansenii, a highly osmo-tolerant and halo-tolerant yeast, maintains activated Dhog1p in the cytoplasm during its growth under severe osmotic stress.
 
Creator Sharma, Pratima
Meena, Netrapal
Aggarwal, Monika
Mondal, Alok K
 
Subject QH426 Genetics
 
Description The HOG pathway is an important mitogen-activated protein kinase (MAPK) signal transduction pathway in Saccharomyces cerevisiae that mediates adaptation of cells to hyper-osmotic stress. Activation of this pathway causes rapid but transient, phosphorylation of the MAPK Hog1p. Phosphorylated Hog1p is rapidly transported to the nucleus that results in the transcription of target genes. The HOG pathway appears to be ubiquitous in yeast. Components of HOG pathway have also been identified in Debaryomyces hansenii, a highly osmotolerant and halotolerant yeast. We have studied activation of HOG pathway in D. hansenii under different stress conditions. Our experiments demonstrated that the pathway is activated by high osmolarity, oxidative and UV stress but not by heat stress. We have provided evidence, for the first time, that D. hansenii maintains phosphorylated Dhog1p in the cytoplasm during its growth under severe osmotic stress.
 
Publisher Springer Science
 
Date 2005-09
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/168/1/mandol2005.pdf
Sharma, Pratima and Meena, Netrapal and Aggarwal, Monika and Mondal, Alok K (2005) Debaryomyces hansenii, a highly osmo-tolerant and halo-tolerant yeast, maintains activated Dhog1p in the cytoplasm during its growth under severe osmotic stress. Current genetics, 48 (3). pp. 162-70. ISSN 0172-8083
 
Relation http://www.springerlink.com/content/n83852510xlr3562/
http://crdd.osdd.net/open/168/