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Potent role of vaccines prepared from macrophages infected with live bacteria in protection against Mycobacterium tuberculosis and Salmonella typhimurium infections.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Potent role of vaccines prepared from macrophages infected with live bacteria in protection against Mycobacterium tuberculosis and Salmonella typhimurium infections.
 
Creator Sharma, Naresh
Agrewala, J N
 
Subject QR180 Immunology
 
Description The present study describes a novel and simple vaccination strategy that involves the culturing of live Mycobacterium tuberculosis and Salmonella typhimurium in syngeneic, allogeneic, and xenogeneic macrophages, followed by drug treatment and gamma irradiation, to kill the bacteria. Notable observations were that the lymphocytes obtained from the vaccinated mice proliferated and secreted mainly interferon- gamma and IgG2a, but not interleukin-4 and IgG1. The enumeration of viability of M. tuberculosis indicated a significant level of protection in the vaccinated mice after challenge with live M. tuberculosis. This vaccination strategy worked successfully for tuberculosis but also showed a significant decrease in mortality of mice challenged with live S. typhimurium.
 
Publisher Oxford University Press
 
Date 2004-07-01
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/210/1/agrewala2004.pdf
Sharma, Naresh and Agrewala, J N (2004) Potent role of vaccines prepared from macrophages infected with live bacteria in protection against Mycobacterium tuberculosis and Salmonella typhimurium infections. The Journal of infectious diseases, 190 (1). pp. 107-14. ISSN 0022-1899
 
Relation http://jid.oxfordjournals.org/content/190/1/107.long
http://crdd.osdd.net/open/210/