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Phenomenological perspectives on the folding of beta/alpha-barrel domains through the modular formation and assembly of smaller structural elements.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Phenomenological perspectives on the folding of beta/alpha-barrel domains through the modular formation and assembly of smaller structural elements.
 
Creator Maiti, Sankar
Luthra-Guptasarma, Manni
Guptasarma, Purnananda
 
Subject QR Microbiology
 
Description The beta/alpha-barrel motif was once considered to be a single protein domain. In recent years, however, it has been shown to consist of smaller substructures displaying the ability to fold autonomously. Here we review the current status of experimental findings concerning the motif's folding behavior in the light of what is currently known about (a) the relative rates of formation of helices and sheets in proteins, in general, and (b) the peculiarities of topology and architecture of the motif, in particular, to develop a detailed phenomenological understanding of how beta/alpha-barrels might form through the modular folding and assembly of substructures.
 
Publisher Wiley
 
Date 2002-10
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/254/1/guptasarma2002.2.pdf
Maiti, Sankar and Luthra-Guptasarma, Manni and Guptasarma, Purnananda (2002) Phenomenological perspectives on the folding of beta/alpha-barrel domains through the modular formation and assembly of smaller structural elements. IUBMB life, 54 (4). pp. 213-21. ISSN 1521-6543
 
Relation http://onlinelibrary.wiley.com/doi/10.1080/15216540214924/pdf
http://crdd.osdd.net/open/254/