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Melatonin enhances Th2 cell mediated immune responses: lack of sensitivity to reversal by naltrexone or benzodiazepine receptor antagonists.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Melatonin enhances Th2 cell mediated immune responses: lack of sensitivity to reversal by naltrexone or benzodiazepine receptor antagonists.
 
Creator Raghavendra, V
Singh, V
Kulkarni, S K
Agrewala, J N
 
Subject QR Microbiology
 
Description Chronic administration of melatonin for 5 days to antigen-primed mice increased the production of pro-inflammatory cytokine IL-10 but decreased the secretion of anti-inflammatory cytokine TNF-alpha. These results further confirm that melatonin activates Th2-like immune response. Whether melatonin-mediated Th2 response is dependent on opioid or central and peripheral benzodiazepine receptors was also examined. Hence, melatonin was administered to antigen-sensitised mice with either naltrexone (a mu opioid receptor antagonist) or flumazenil (a central benzodiazepine receptor antagonist) or PK11195 (a peripheral benzoidiazepine receptor antagonist). No significant difference in melatonin-induced Th2 cell response was observed by naltrexone, flumazenil or PK11195 treatment. These findings suggest that the Th2 cell response induced by melatonin in antigen sensitised mice neither dependent on endogenous opioid system nor is modulated through the central or peripheral benzodiazepine receptors.
 
Publisher Springer Science
 
Date 2001-05
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/291/1/agrewala2001.pdf
Raghavendra, V and Singh, V and Kulkarni, S K and Agrewala, J N (2001) Melatonin enhances Th2 cell mediated immune responses: lack of sensitivity to reversal by naltrexone or benzodiazepine receptor antagonists. Molecular and cellular biochemistry, 221 (1-2). pp. 57-62. ISSN 0300-8177
 
Relation http://www.springerlink.com/content/k272048720323787/fulltext.pdf
http://crdd.osdd.net/open/291/