ICAR Research Data Repository for Knowledge Management
Effect of the alpha-methyl substituent on chemoselectivity in esterase-catalyzed hydrolysis of S-acetyl sulfanylalkanoates.
DIR@IMTECH: CSIR-Institute of Microbial Technology
View Archive Info| Field | Value | |
| Title |
Effect of the alpha-methyl substituent on chemoselectivity in esterase-catalyzed hydrolysis of S-acetyl sulfanylalkanoates.
|
|
| Creator |
Kumar, Ish
Jolly, R S |
|
| Subject |
QD Chemistry
|
|
| Description |
The isomeric compounds 1 and 3, which differ only in the position of a methyl substituent, give opposite chemoselectivities in an esterase-catalyzed hydrolysis reaction. The esterase was chemoselective for the oxoester in 1, but for the thiol ester group in 3. A high enantioselectivity was observed for both 1 and 3.
|
|
| Publisher |
ACS Publications
|
|
| Date |
1999-07-29
|
|
| Type |
Article
PeerReviewed |
|
| Format |
application/pdf
|
|
| Identifier |
http://crdd.osdd.net/open/313/1/jolly1999.pdf
Kumar, Ish and Jolly, R S (1999) Effect of the alpha-methyl substituent on chemoselectivity in esterase-catalyzed hydrolysis of S-acetyl sulfanylalkanoates. Organic letters, 1 (2). pp. 207-9. ISSN 1523-7060 |
|
| Relation |
http://pubs.acs.org/doi/pdfplus/10.1021/ol990544%2B
http://crdd.osdd.net/open/313/ |
|