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Role of an ABC importer in mycobacterial drug resistance.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Role of an ABC importer in mycobacterial drug resistance.
 
Creator Chakraborti, Pradip K
Bhatt, K
Banerjee, S K
Misra, P
 
Subject QR Microbiology
 
Description Phosphate specific transporter (Pst) in bacteria is involved in phosphate transport. Pst is a multisubunit system which belongs to the ABC family of transporters. The import function of this transporter is known to be operative at media phosphate concentrations below the millimolar range. However, we found amplification of this transporter in a laboratory generated ciprofloxacin resistant Mycobacterium smegmatis colony (CIPr) which was grown in a condition when phosphate scavenging function of this operon was inoperative. Our results therefore argue the role of this ABC importer in conferring high level of fluoroquinolone resistance in CIPr.
 
Publisher Springer Science
 
Date 1999-08
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/337/1/chakraborti99.pdf
Chakraborti, Pradip K and Bhatt, K and Banerjee, S K and Misra, P (1999) Role of an ABC importer in mycobacterial drug resistance. Bioscience reports, 19 (4). pp. 293-300. ISSN 0144-8463
 
Relation http://www.springerlink.com/content/r43352x16r413t93/
http://crdd.osdd.net/open/337/