Record Details

Regulation of secretion of IL-4 and IgG1 isotype by melatonin-stimulated ovalbumin-specific T cells.

DIR@IMTECH: CSIR-Institute of Microbial Technology

View Archive Info
 
 
Field Value
 
Title Regulation of secretion of IL-4 and IgG1 isotype by melatonin-stimulated ovalbumin-specific T cells.
 
Creator Shaji, A V
Kulkarni, S K
Agrewala, J N
 
Subject QR180 Immunology
 
Description In the present study, we describe the potential role of melatonin, a pineal hormone, in regulating the activation of the antigen-specific T cell response. Melatonin encouraged the proliferation of Th cells and improved their ability to secrete IL-4, but down-regulated the levels of IL-2 and interferon-gamma (IFN-gamma). Melatonin, however, could not exert any influence on the T cells of unprimed mice. On studying the regulation of subclass of IgG isotype, melatonin specifically enhanced the secretion of antigen-specific IgG1 antibodies and decreased the yield of IgG2a isotype. The results suggest that melatonin possibly acts by selectively activating a Th2-like immune response.
 
Publisher Blackwell Science / Oxford
 
Date 1998-01
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://crdd.osdd.net/open/361/1/agrewala98.1.pdf
Shaji, A V and Kulkarni, S K and Agrewala, J N (1998) Regulation of secretion of IL-4 and IgG1 isotype by melatonin-stimulated ovalbumin-specific T cells. Clinical and experimental immunology, 111 (1). pp. 181-5. ISSN 0009-9104
 
Relation http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2249.1998.00493.x/pdf
http://crdd.osdd.net/open/361/