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Regulation of secretion of IL-4 and IgG1 isotype by melatonin-stimulated ovalbumin-specific T cells.
DIR@IMTECH: CSIR-Institute of Microbial Technology
View Archive Info| Field | Value | |
| Title |
Regulation of secretion of IL-4 and IgG1 isotype by melatonin-stimulated ovalbumin-specific T cells.
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| Creator |
Shaji, A V
Kulkarni, S K Agrewala, J N |
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| Subject |
QR180 Immunology
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| Description |
In the present study, we describe the potential role of melatonin, a pineal hormone, in regulating the activation of the antigen-specific T cell response. Melatonin encouraged the proliferation of Th cells and improved their ability to secrete IL-4, but down-regulated the levels of IL-2 and interferon-gamma (IFN-gamma). Melatonin, however, could not exert any influence on the T cells of unprimed mice. On studying the regulation of subclass of IgG isotype, melatonin specifically enhanced the secretion of antigen-specific IgG1 antibodies and decreased the yield of IgG2a isotype. The results suggest that melatonin possibly acts by selectively activating a Th2-like immune response.
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| Publisher |
Blackwell Science / Oxford
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| Date |
1998-01
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://crdd.osdd.net/open/361/1/agrewala98.1.pdf
Shaji, A V and Kulkarni, S K and Agrewala, J N (1998) Regulation of secretion of IL-4 and IgG1 isotype by melatonin-stimulated ovalbumin-specific T cells. Clinical and experimental immunology, 111 (1). pp. 181-5. ISSN 0009-9104 |
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| Relation |
http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2249.1998.00493.x/pdf
http://crdd.osdd.net/open/361/ |
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