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Attempts to characterize the mechanisms involved in the growth inhibition of Mycobacterium microti in interferon-gamma or tumor necrosis factor-alpha activated J774A.1 cells.

DIR@IMTECH: CSIR-Institute of Microbial Technology

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Title Attempts to characterize the mechanisms involved in the growth inhibition of Mycobacterium microti in interferon-gamma or tumor necrosis factor-alpha activated J774A.1 cells.
 
Creator Gupta, R
Dogra, N
Raje, Manoj
Majumder, S
 
Subject QR Microbiology
 
Description The growth of Mycobacterium microti was inhibited within J774A.1 macrophage cells activated with either interferon-gamma or tumor necrosis factor-alpha. Activation with interferon-gamma or tumor necrosis factor-alpha alone did not stimulate the production of nitrite in J774A.1 cells. Interferon-gamma but not tumor necrosis factor-alpha increased the production of hydrogen peroxide in a concentration dependent manner but scavengers of reactive oxygen species did not influence the growth inhibiting effect of interferon-gamma within J774A.1 cells. Both interferon-gamma and tumor necrosis factor-alpha enhanced the fusion of M. microti containing phagosomes with lysosomes and the ultimate degradation of bacteria. Our results showed that growth inhibition of M. microti within interferon-gamma or tumor necrosis factor-alpha stimulated J774A.1 cells was independent of reactive oxygen intermediate and reactive nitrogen intermediate production.
 
Publisher Wiley
 
Date 1996-07-01
 
Type Article
PeerReviewed
 
Relation http://onlinelibrary.wiley.com/doi/10.1111/j.1574-6968.1996.tb08332.x/pdf
http://crdd.osdd.net/open/381/
 
Identifier Gupta, R and Dogra, N and Raje, Manoj and Majumder, S (1996) Attempts to characterize the mechanisms involved in the growth inhibition of Mycobacterium microti in interferon-gamma or tumor necrosis factor-alpha activated J774A.1 cells. FEMS microbiology letters, 140 (2-3). pp. 171-8. ISSN 0378-1097